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“Why Caffeine Makes You Sharp - or Shaky: The DNA Behind It All”

  • Writer: Robin Shatz
    Robin Shatz
  • Aug 6
  • 2 min read

Ok so Caffeine isn’t just about our favorite coffee or tea. It’s about your genetics - and how your body processes stimulation, stress, and energy. If you’ve ever felt amazing after an espresso - or on the verge of a panic attack - you’re not imagining it. It’s in your DNA!!!


What is at the heart of it?

A gene called CYP1A2 - the master switch for how fast (or slow) your body clears caffeine. Let’s take a closer look…


🔆Fast vs. Slow Metabolizers - What’s the Difference?


☕️Fast Metabolizer (CYP1A2 “AA” Type):

*Breaks down caffeine quickly

*Gets a boost without prolonged crash

*Can drink coffee late in the day with little effect on sleep

*May even have a reduced risk of heart issues with moderate intake

*Feels sharp, energized, focused after caffeine


🐢Slow Metabolizer (CDYP1A2 “AC” or “CC” Type):

*Breaks down caffeine slowly

*Caffeine lingers in the bloodstream

*Can experience anxiety, racing heart, insomnia, irritability - even on small amounts

*Higher risk of hypertension and heart issues with regular caffeine use

*May feel mentally foggy or overstimulated - not sharp


🧠Caffeine + The Brain

Pros (for fast metabolizers or low - to - moderate intake):

*Boosts dopamine and focus

*Increases alertness

*Supports memory formation

Cons (especially for slow metabolizers or overuse):

*Triggers anxiety or panic

*Increases cortisol and adrenaline (stress response)

*Disrupts sleep (even hours after consumption)

*Contributes to burnout or emotional fragility

*Can worsen PMS, perimenopause symptoms, or hormone sensitivity


❤️‍🔥Caffeine + Emotions + Hormones:

*For slow metabolizers, caffeine can feel like a trauma trigger:

*Racing thoughts, sensitivity, heart palpitations, emotional reactivity

*It can disrupt emotional regulation, especially if paired with stress, poor sleep,or nutrient depletion (magnesium, B vitamins)

*If you’re already dysregulated (anxiety, depression, trauma history)… caffeine can add fuel to the fire


🧬How to Work With Your Genetics (Not Against Them)

If You’re a FAST Metabolizer:

*You probably tolerate 1-3 cups per day

*Still stop by 2-3pm to protect deep sleep

*Look for signs of overstimulation (racing thoughts = too much)

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If You’re a SLOW Metabolizer:

*Stick to caffeine - free or decaf (matcha, chicory, herbal blends)

*Try B vitamins, L-theanine, or adaptogens instead

*Never consume caffeine on an empty stomach

*Support detox pathways (liver, gut, methylation)


🧠Let’s Take a Final Look:


The way caffeine hits you isn’t about will power.

It’s about how your body processes stimulation, pressure, and recovery.

If you’ve been blaming yourself for not “handling” coffee/tea… stop.

Your DNA is just trying to tell you something.

STOP - and LISTEN!!!



 
 
 

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