“Why Caffeine Makes You Sharp - or Shaky: The DNA Behind It All”
- Robin Shatz
- Aug 6
- 2 min read
Ok so Caffeine isn’t just about our favorite coffee or tea. It’s about your genetics - and how your body processes stimulation, stress, and energy. If you’ve ever felt amazing after an espresso - or on the verge of a panic attack - you’re not imagining it. It’s in your DNA!!!
What is at the heart of it?
A gene called CYP1A2 - the master switch for how fast (or slow) your body clears caffeine. Let’s take a closer look…
🔆Fast vs. Slow Metabolizers - What’s the Difference?
☕️Fast Metabolizer (CYP1A2 “AA” Type):
*Breaks down caffeine quickly
*Gets a boost without prolonged crash
*Can drink coffee late in the day with little effect on sleep
*May even have a reduced risk of heart issues with moderate intake
*Feels sharp, energized, focused after caffeine
🐢Slow Metabolizer (CDYP1A2 “AC” or “CC” Type):
*Breaks down caffeine slowly
*Caffeine lingers in the bloodstream
*Can experience anxiety, racing heart, insomnia, irritability - even on small amounts
*Higher risk of hypertension and heart issues with regular caffeine use
*May feel mentally foggy or overstimulated - not sharp
🧠Caffeine + The Brain
Pros (for fast metabolizers or low - to - moderate intake):
*Boosts dopamine and focus
*Increases alertness
*Supports memory formation
Cons (especially for slow metabolizers or overuse):
*Triggers anxiety or panic
*Increases cortisol and adrenaline (stress response)
*Disrupts sleep (even hours after consumption)
*Contributes to burnout or emotional fragility
*Can worsen PMS, perimenopause symptoms, or hormone sensitivity
❤️🔥Caffeine + Emotions + Hormones:
*For slow metabolizers, caffeine can feel like a trauma trigger:
*Racing thoughts, sensitivity, heart palpitations, emotional reactivity
*It can disrupt emotional regulation, especially if paired with stress, poor sleep,or nutrient depletion (magnesium, B vitamins)
*If you’re already dysregulated (anxiety, depression, trauma history)… caffeine can add fuel to the fire
🧬How to Work With Your Genetics (Not Against Them)
If You’re a FAST Metabolizer:
*You probably tolerate 1-3 cups per day
*Still stop by 2-3pm to protect deep sleep
*Look for signs of overstimulation (racing thoughts = too much)

If You’re a SLOW Metabolizer:
*Stick to caffeine - free or decaf (matcha, chicory, herbal blends)
*Try B vitamins, L-theanine, or adaptogens instead
*Never consume caffeine on an empty stomach
*Support detox pathways (liver, gut, methylation)
🧠Let’s Take a Final Look:
The way caffeine hits you isn’t about will power.
It’s about how your body processes stimulation, pressure, and recovery.
If you’ve been blaming yourself for not “handling” coffee/tea… stop.
Your DNA is just trying to tell you something.
STOP - and LISTEN!!!



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